8:25 Welcome Address And Chairperson’s Opening Remarks

Rose Gonzales, PhD
Director, Analytical Chemistry & Sample Logistics
Pfizer Global R&D

8:30 OPENING KEYNOTE: Proposing Senior Management Buy-In For Your Compound Management Department

• Managing change in the collaborative role of CM in the drug discovery organization – how can we be the most flexible in our integrated role?
• Responding to new requirements and trends in target based screening
• Understanding and justifying the secret to success of managing a CM team to your senior management
• Demonstrating the value of CM to key partners - both internal and external

9:15Assay-ready Plates for Screening, Hit Follow-up, and SAR at Amgen

• Describing the role of assay ready plates in sample management and lead discovery
• Monitoring compound integrity in assay-ready plates stored under various conditions using sentinel assays
• Using statistical analysis to assess differences in assay-ready plate storage conditions
• Describing high-throughput LC-MS QC of assay-ready dose response plates
• Improving hit confirmation and dose response infrastructure to drive efficient hit follow-up

John McCarter
Principal Scientist, Lead Discovery
Amgen

10:00 Beyond Lean/Agile: How Compound Management Drives Project Execution & Strategy And Assay Ready Plates For Lead Optimization: Protecting Compound Integrity While Increasing Quality

• Implementing Lean/Agile Principles in Lead Optimization
• Defining and measuring success with the right metrics
• Taking advantage of the human component
• Discussing compound integrity recommendations and Assay Ready Plates
• Examining implementation techniques and the use of Assay Ready Plates in Lead Optimization
• Understanding the effect on data quality

11:30 Successfully Handling And Managing Fluctuating Request Demands While Keeping Internal Customers Satisfied

• Addressing the challenge of scale up in quantity through the use of automation
• Improving the quality of materials supplied to screening
• Supporting on-demand requests for library subsets
• Developing storage products to facilitate higher throughput and to incorporate compound QC
• Improving levels of process integrity through the consistency of automated handling

Paul McCoy
Principal Automation Engineer
Lundbeck

12:15 PANEL DISCUSSION: Effectively Managing Your Compound Inventory With Limited Resources

• Understanding CM best practices for lead identification
• Discussing effective strategies and methods for simplifying the process without threatening QA
• Cutting costs on the consumerables and effective waste elimination
• Understanding if you are saving or making money in the long run

Panelists:

2:00 Setting A Global Strategy For Multi-Site Compound Management

• Creating A 10 Year Vision And Roadmap For Revamping The Central Archive
• Producing Fully Enabled Satellite Sites
• Encompassing Both Design, And Buy-In Elements
• Addressing And Including Policy Decisions And Trade-Offs To Be Made

Sarah Steklov
Group Leader, Compound Management
Vertex Pharmaceuticals

2:45 Interactive Roundtable Best Practice Discussions

After A Jam-Packed Day Of Big Picture Keynotes, Panel Discussions, Case Studies, And Presentations, The 5th CMI Gives You The Chance To Meet And Brainstorm With Small Groups Of Your Peers During Our Interactive Roundtable Discussions. This Is A Great Opportunity To Make Valuable Contacts From Your Area Of Interest, And To Deep-Dive Into The Tricky Details That You May Missed In The Course Of The Day’s Sessions. MUST ATTEND!

** Delegates Are Encouraged To Bring Their Own Data Or Study Results Or Submit Them Earlier To Simon.curtis@iqpc.com

Round Tables Include:

• Global Logistical Challenges In The Chemical Compound Supply Chains, Cross-Border Transportation And Regulatory Compliances
• Compound Registration: A New Hub For Social Research Networks
• Examining Models Of Outsourced Compound Management And Financial Comparisons
• Compound Data Integration Post Merger

4:00 Successfully Maintaining And Motivating Talented Compound Management Team Members

• Discussing the new role of the Compound Management department
• Understanding the strengths and talents of your team
• Rewarding and incentivizing individuals and team performance
• Building a strategic partnership with your internal customers
• Taking proactive steps to deliver a quality product and service

Collette Dechard
Manager, Compound Management Group
Merck

4:45 Workflow Automation For Analytical QC Data Analysis To Support Compound Collection Integrity

• Describing LC/MS/UV data and analysis of compound quality using pipeline pilot scripts
• Strategizing multiple-tier screening assays for the simultaneous determination of identity confirmation and purity determination of file collection compounds
• Improving efficiency of the analytical QC screening results to support compound collection integrity
• Discussing high throughput compound collection QC screening points
• Understanding current high throughput technology for optimizing compound identification and quality

Navin Varshney
Scientist II Chemical Technologies
Schering Plough Research Institute

5:30 A Simple And Robust Method For Quality Control Of SAR Assay-Ready Plates

• Implementing analytical stock sample QC (identity, purity, concentration) for all SAR compounds
• Examining why this stock solution QC does not reflect what happens to the compounds in storage, during processing, or dispensing into dose-response assay-ready plates
• Describing a simple and rapid UV scan-based method to QC the end-product assay-ready plates
• Understanding the data – A direct comparison of the solution dispensed for screening with the stock solution
• Discussing the errors detected and the source of error (where it could be identified)
• Displaying the advantages – simple, robust, inexpensive, and high-throughput

Ioana Popa-Burke
Investigator, Sample Management Technologies
GlaxoSmithKline

6:15 Chairperson’s Closing Remarks And End Of Day One